Skip to main content
. 2011 Dec 7;31(49):18094–18103. doi: 10.1523/JNEUROSCI.4136-11.2011

Figure 3.

Figure 3.

Morphine-induced activation of GTPase was suppressed in Nox1−/Y. a, Activation of [35S]GTPγS-binding induced by increasing the concentration of morphine in the dorsal spinal cord membrane obtained from untreated mice. Values were obtained from 10 to 11 animals per group. b, Effects of increasing the concentration of morphine on GTP hydrolysis in the presence of 0.3 μm (left) or 1 μm GTP (right). The membrane fraction was obtained from the dorsal spinal cord. *p < 0.05, **p < 0.01 compared with control. #p < 0.05 compared with Nox1+/Y. Values were obtained from 9 to 10 animals per group. c, Expression of RGS mRNA in the dorsal spinal cord. Values were obtained from 4 animals per group.