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Model of the PrP-reggie-mediated recruitment of N-cadherin (cargo) to the growth cone. Before PrP activation, PrP and reggie are partially associated with one another along neurites and in growth cones. PrP activation enhances PrP-reggie complex formation, induces reggie-dependent activation of fyn and MAPK, which mobilizes N-cadherin and the TC10- and Exo70-dependent delivery of the cargo to the growth cone. This promotes growth cone formation and neurite outgrowth.
