Table 2.

Clusters showing significant increases in activation during the pain localizer session: Noxious versus non-noxious (critical cluster size: 145 voxels)

	Side	Coordinates			Cluster size
		x	y	Z
Insula	R	36	14	0	28723***
Putamen/pallidum	R	26	0	0
Middle frontal gyrus	R	34	42	20
Midbrain	M	0	14	−8
Middle cingulate cortex	M	−4	6	32
Anterior cingulate cortex	M	2	12	24
Insula	L	−30	18	8
Putamen/pallidum	L	−20	2	−2
Supramarginal gyrus	L	−62	34	26
Parietal operculum	L	−58	20	18
Cerebellum	L	−24	−68	−28	8397***
	R	20	−66	−36
Supramarginal gyrus	R	64	−38	32	3693***
Parietal operculum	R	62	−20	22
Middle frontal gyrus	L	−34	32	30	940**
Middle temporal gyrus	R	50	−28	−12	185*

All clusters survived correction for multiple comparisons over the whole brain. Coordinates (in standard MNI space) refer to maximally activated foci: x = distance (mm) to the right (+) or left (−) of the midsagittal line; y = distance anterior (+) or posterior (−) to the vertical plane through the anterior commissure; z = distance above (+) or below (−) the intercommissural line. L, Left hemisphere; R, right hemisphere; M, medial activations.

***p < 0.001, **p < 0.01, *p < 0.05, permutation-based correction for multiple comparisons.