Table 4.

Amino Acid Interactions Between NKG2A/CD94 and HLA-E with Leader Peptide from HLA-G

HLA-E α1		HLA-E α1		HLA-E α2
CD94	helix	CD94	helix	NKG2A	helix
H-bonds		van der Waal contacts		H-bonds
Ser77 = Arg65		Ser77 = Arg65		Arg137 = Ser151
Gln112 = Glu152		Gln112 = Ile73		Lys217 = Asp162
Gln113 = Asp69		Gln113 = Asp65
Ser143 = Arg79		Gln113 = Asp69		Salt linkage
Thr146 = Glu89		Phe114 = Glu72		Arg137 = Ser151
Asn160 = Arg79		Phe114 = Val76		Lys199 = Asp162
Asn160 = Arg79 (second)		Ser143 = Arg79
Ala161 = Arg79		Thr146 = Glu89		van der Waal contacts
Glu164 = Gln72		Phe147 = Arg79		Arg137 = Ser151
Glu168 = Glu19		Asn160 = Val76		Arg137 = Glu154
Arg171 = Arg65		Asn160 = Arg79		Lys164 = Arg65
		Ala161 = Val76		Pro171 = His155
Salt linkage		Ala161 = Arg79		Ser172 = His155
Asp163 = Arg75		Leu162 = Gln72		Lys199 = Asp162
Arg171 = Asp69		Leu162 = Arg75		Gln212 = Ala158
		Leu162 = Val76		Gln212 = Glu154
		Asp163 = Arg75		Val213 = His155
		Glu164 = Glu19		Lys217 = Asp162
		Glu164 = Gln72		Lys217 = Ala158
		Asn170 = Gln72		Ser223 = Arg131
		Arg171 = Arg65		Ser224 = Arg131

Modified from Petrie et al.⁽⁴⁸⁾