Table 5.
Documention Cell Surface Expression of HLA-E on Human Cancers: Monoclonal Antibodies Used Include MEM-E/02, MEM-E/06, MEM-E/07, MEM-E/08, 3D12, 3H2679, and TFL-033
| mAbs used | Cancer types |
|---|---|
| MEM-E/02 | Melanoma(86) |
| Lip squamousal cell carcinoma(87) | |
| Laryngeal carcinoma(88) | |
| Vulvar intraepithelial carcinoma(76) | |
| Penile cancer(89) | |
| Glioblastomas(77,90,91) | |
| Oral osteosarcoma(92) | |
| Intraoral mucoepidermoid carcinoma(93) | |
| Rectal cancer(94) | |
| Colorectal carcinoma(78,95–99) | |
| Colon carcinoma(97) | |
| Hepatocellular carcinoma(100) | |
| Nonsmall cell lung carcinoma(101) | |
| Breast cancer(102,103) | |
| Ovarian cancer/cervical cancer(104) | |
| Cervical cancer(105,106) | |
| Cervical squamosal and adenocarcinoma(107) | |
| Serous ovarian adenocarcinoma(108,109) | |
| Renal cell carcinoma(110,111) | |
| Thyroid cancer(112) | |
| Hodgkin lymphoma(113) | |
| 3D12 | Many cancers(114) |
| Melanoma, cervical cancers(115) | |
| Glioblastoma stem cells(116) | |
| Glioblastoma(117) | |
| Neuroblastoma(118) | |
| Chronic lymphocytic leukemia(119,120) | |
| 3H2679 | Neuroblastoma(121) |
| Colorectal carcinoma(122) | |
| MEM-E/06 | Colon carcinoma and leukemia (K562)(123) |
| MEM-E/07 and MEM-E/08 | Melanoma and other cancers(123) |
| MEM-E/08 | Colorectal carcinoma(124,125) |
| TFL-033 and MEM-E/02 | Gastric cancer(126) melanoma(54) |
mAbs, monoclonal antibodies.