Table 3.

The main pharmacokinetic parameters in SD rats after intravenous injection of CPT-11, moeixitecan (M) ,and moeixitecan-loaded liposomal nanoparticles (MLP) (n=3)

Parameters	CPT-11	M	MLP
Dose (mg/kg)	5	5	5
AUC0-∞(h×ng/mL)	118±8	774±129	3454±352
Cmax (ng/mL)	56.1±10.7	137±8.0	616±43.4
tmax	0.083±0.000	0.229±0.197	0.265±0.190
T1/2(h)	1.730±0.106	2.420±0.195	5.230±0.620
MRT (h)	2.443±0.089	4.641±0.103	6.700±1.470

Note: Data are presented as mean±standard deviation.