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| Laboratory investigation | Value | Change from baseline value |
| Uric acid | ≥ 476 μmol/mL (> 8 mg/dL) | Increase by 25% |
| Phosphorus | ≥ 1.45 mmol/L (> 4.5 mg/dL) | Increase by 25% |
| Potassium | ≥ 6.0 mmol/L (> 6 mEq/L) | Increase by 25% |
| Corrected calcium | ≤ 1.75 mmol/L (<7 mg/dl) | Decrease by 25% |
