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Kinetic parameters for LSD1 and the splicing variants
| kcat (min−1)a | Km (μm)a | |
|---|---|---|
| LSD1 + CoREST | 7.35 ± 0.28b | 5.12 ± 1.04b |
| LSD1-2a + CoREST | 9.38 ± 0.65 | 6.31 ± 1.44 |
| LSD1-8a + CoREST | 5.19 ± 0.48 | 4.55 ± 1.65 |
| LSD1-2a/8a + CoREST | 5.47 ± 0.20 | 7.52 ± 1.00 |
aApparent steady-state kinetic parameters were determined as described by using a 21 aa H3 peptide monomethylated at Lys4 (Forneris et al., 2005).
bData were taken from Forneris et al. (2007).
