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Localization of oxidative stress PV-IR in CA1 and CA3 of ventral hippocampus of adult GCLM +/+ and −/− mice. A, E, DAPI staining of cell nuclei (blue). B, F, DNA oxidation as revealed with 8-Oxo-dG labeling (green). C, G, PV-IR (red). D, H, Colocalization of the markers. 8-Oxo-dG labeling is strong in CA3 and weaker in CA1 of GCLM −/− (F), but absent in +/+ mice (B). A reduction of PV-IR FSI in GCLM −/− (G), as compared to +/+ (C) mice, is also observed. Scale bar, 200 μm.
