Figure 6.

Quantification of oxidative stress using 8-Oxo-dG labeling in ventral hippocampus of adult GCLM +/+ (n = 5) and −/− mice (n = 5). A, Mean fluorescent intensity of 8-Oxo-dG-labeled voxels (represents level of oxidative stress). The fluorescent intensity is significantly higher in all regions of the ventral hippocampus of GCLM −/− compared to +/+ mice. B, Number of voxels labeled with 8-Oxo-dG (represents the extent of oxidative stress). The number of labeled voxels is significantly higher in all regions of the ventral hippocampus of GCLM −/− compared to +/+ mice. Note that 8-Oxo-dG labeling (based on mean intensity and number of labeled voxels) is particularly strong in DG and CA3. Data are presented with the quartiles (bar), median (horizontal line inside the bar), mean (circle), and outliers (triangle). **p < 0.01, *p < 0.05.