Figure 3.
nNOS is required for the effects of 5-HT1AR agonist and antagonist on anxiety-related behavior. A, The latency to feed in the NSF test in nNOS KO and WT mice treated with 8-OH-DPAT or vehicle for 28 d (n = 9–10). B, C, The number of entered inner fields (B) and of entered total fields (C) for nNOS KO and WT mice treated with 8-OH-DPAT or vehicle for 28 d in the open field (n = 10). D, The latency to feed in the NSF test in mice treated with NAN-190 or 7-NI or the combination of the two drugs for 28 d (n = 9–10). E, The latency to feed in the NSF test in the mice treated with NAN-190 or 7-NI or the combination of two drugs for 28 d (n = 9–10). Error bars represent means ± SEM. *p < 0.05, versus vehicle; #p < 0.05, versus NAN-190.