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Neuronal NOS inhibition abolishes the anxiogenic-like effect of 5-HT1AR dysfunction. NAN-190 (4.74 μg), 7-NI (16.31 μg), or both in combination (NAN-190 was injected at 30 min after 7-NI injection) was microinjected into the bilateral hippocampi of adult mice. A–C, The latency to feed in the NSF test (A) and time spent in open arms (B) and number of entries in the arms (C) in the EPM test were measured at 21 d after treatments. Error bars represent means ± SEM. n = 9∼12; *p < 0.05.
