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. 2010 Jun 16;30(24):8138–8150. doi: 10.1523/JNEUROSCI.0256-10.2010

Figure 5.

Figure 5.

Postsynaptic Cdc42, Wsp, and the Arp2/3 complex regulate synaptic growth at the NMJ. A–E, Confocal images of NMJs 6/7 labeled with anti-HRP in BG57-GAL4/+ (A), UAS-cdc42RNAi/+; BG57-GAL4/+ (B), BG57-GAL4/UAS-wspRNAi (C), UAS-arp2RNAi/+; BG57-GAL4/+ (D), and BG57-GAL4/UAS-arp3RNAi (E) third instar larvae. The columns on the right are higher-magnification views of NMJ terminals marked in the low-magnification panels by boxes. Note that when expressed specifically in muscles, cdc42, wsp, arp2, and arp3 dsRNAs increase satellite bouton formation similarly. Scale bar, 50 μm. F–H, Quantification of total bouton number (F), satellite bouton number (G), and total NMJ length (H) at NMJ 6/7 in the genotypes indicated. The number of NMJs quantified for each genotype is indicated inside the bars. Comparisons are with the control BG57-GAL4/+ or C155-GAL4/+ line (*p < 0.05; **p < 0.01; ***p < 0.001). Raw data are shown in supplemental Table 2 (available at www.jneurosci.org as supplemental material).