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. 2010 Jun 23;30(25):8411–8420. doi: 10.1523/JNEUROSCI.5736-09.2010

Figure 3.

Figure 3.

Wnt-5a ligand increases the amplitude of evoked IPSC, without affecting the paired-pulse index. Intracellular recording of a CA1 pyramidal cells after Wnt-5a ligand treatment at a holding membrane potential of 0 mV and in the presence of 50 μm APV and 20 μm CNQX. A, Averaged evoked IPSCs by paired-pulse protocols (eIPSCs), before (Aa) and after 15 min (Ab) of continued perfusion with Wnt-5a. Time course of the effect of Wnt-5a (black circles) on eIPSC amplitudes is shown. B, Quantification of the average amplitude of eIPSCs before (media) and after 15 min of treatment (control or Wnt-5a). C, Determination of the PPR index before (media) and after 15 min of treatment (control or Wnt-5a). “Media” corresponds to the values of eIPSCs when the cells have not been treated. “Control” corresponds to the values of eIPSCs when the cells were treated with vehicle. Error bars indicate SEM (n = 10). *p < 0.01.