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. 2010 Oct 20;30(42):14046–14058. doi: 10.1523/JNEUROSCI.2128-10.2010

Figure 8.

Figure 8.

Inhibition of tyrosine hydroxylase activity suppresses DA levels and daytime PER2 expression in the dorsal striatum. Rats were given three injections of AMPT or saline over 8 h and then killed at either ZT13 (5 h after the last injection) or ZT1 (17 h after the last injection). a, DA content in the dorsal striatum (expressed as picograms of DA/microgram of protein) in AMPT-injected rats (black bars) was significantly decreased at both ZT1 and ZT13 compared with saline-injected rats (white bars; n = 2 per treatment group per ZT; *p < 0.05). b, In the dorsal striatum, AMPT treatment decreased daytime PER2 expression at ZT1 and increased PER2 at ZT13 compared with saline controls (expressed as mean PER2-IR nuclei ± SEM at each ZT; n = 4 per treatment group per ZT; *p < 0.05). c, In the SCN, AMPT treatment had no effect on PER2 expression at either time point.