Figure 9.

A unilateral 6-OHDA infusion into the MFB has no effect on PER2 in primary motor cortex (M1) or in the dentate gyrus (DG), whereas treatment with AMPT strongly suppresses the normal peak of PER2 expression in each of these regions. Mean PER2-IR nuclei ± SEM in the intact and 6-OHDA-lesioned hemispheres of M1 (a) and DG (c) after a unilateral 6-OHDA lesion (n = 5 per ZT). Mean PER2-IR nuclei ± SEM in primary motor cortex (b) and DG (d) after AMPT treatment (n = 4 per treatment group per ZT; *p < 0.05).