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. 2010 Oct 20;30(42):14059–14067. doi: 10.1523/JNEUROSCI.3883-10.2010

Figure 3.

Figure 3.

The 14-3-3 antagonist R18 blocks MAG-dependent repulsion of E13 chick DRG neurons. a, b, Rose histograms illustrate turning responses of E13 chick DRG neurons in response to a MAG-Fc gradient (200 ng/ml in outer chamber) in a Dunn chamber turning assay. Neurons were transduced with HSV-WLRL (a) or HSV-R18 (b) for 12–16 h before the turning assay. c, An overlay of the rose histograms presented in a and b illustrating a large population of R18-positive neurons with an attractive turning response to a MAG gradient. d, Mean turning angles of noninfected, WLRL- or R18-transduced E13 chick DRG neurons in the absence of a gradient or in response to MAG. Numbers within the bars indicate the number of growth cones measured over at least three independent experiments. Statistics were performed by one-way ANOVA with Tukey's post hoc test. *p < 0.05 compared with no gradient control; #p < 0.05 compared with the MAG-dependent repellent response in WLRL-transduced neurons.