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. 2010 Oct 20;30(42):14194–14204. doi: 10.1523/JNEUROSCI.3145-10.2010

Figure 6.

Figure 6.

EEG spectra during and after the drug-induced state for the highest doses of BAC (10 mg/kg) and GBL (300 mg/kg). All spectra (0.75–90 Hz; at 0.25 Hz bins) were expressed as a percentage of the NREMS EEG spectrum averaged over the last 4 h of the baseline rest period, thereby allowing direct comparison among genotypes, drugs, and conditions. A, BAC- and GBL-induced state EEG spectra in WT mice (blue and red lines, respectively). For comparison, EEG spectra during the first 20 min of NREMS after 6 h sleep deprivation (SD; black) and after saline administration (gray line) were included. Spectra significantly differed among conditions (two-way ANOVA for factors condition, bin, and interaction, p < 0.0001). Horizontal colored lines indicate frequency bins in which EEG power significantly differed (GBL vs SD, red; BAC vs SD, blue; GBL vs BAC, black; Tukey's test, p < 0.05). The GBL-induced state EEG spectrum differed strongly from that of the BAC-induced state, especially in the low delta (0.75–1.75 Hz) frequencies and for frequencies >3 Hz. B, GBL-induced state spectra in 1a−/−, 1b−/−, and WT mice (light gray, dark gray, and black lines, respectively; WT same as in A). Spectra significantly differed among genotypes (two-way ANOVA for factors genotype, bin, and interaction, p < 0.0001). Horizontal colored lines mark frequency bins in which genotypes differed (1a−/− vs 1b−/−, black; 1b−/− vs WT, dark gray; 1a−/− vs WT, light gray; Tukey's test, p < 0.05). EEG changes in 1b−/− mice closely resembled those of WT. C, EEG spectra during the first 20 min of NREMS after GBL- (red) and BAC- (blue) induced state and after SD (black) and saline (gray line) in WT mice. SD and saline spectra same as in A. Spectra were affected by condition (two-way ANOVA for factors condition, bin, and interaction, p < 0.0001; Tukey's test for genotype, p < 0.05), largely due to the low spectral values reached after GBL in frequencies <7 Hz. Statistics and color coding as in A. D, EEG spectra during the first 20 min of NREMS after GBL-induced state in 1a−/−, 1b−/−, and WT mice (color coding as in B). Spectra significantly differed among genotypes (two-way ANOVA for factors genotype, bin, and interaction, p < 0.0001; statistics and color coding as in B).