Table 4. List of significant genes with both disease free and overall survival of different clinic-pathological parameters in TCGA laryngopharyngeal cohort.
| S.No | Clinico-pathological parameter | Genes | Overall Survival Logrank Test P-Value | Disease Free Survival Logrank Test P-Value# |
|---|---|---|---|---|
| 1 | Entire cohort | IL1RAP | 0.015 | 3.47e-06 |
| RYK | 0.00979 | 7.25e-04 | ||
| AP2M1 | 0.0288 | 0.00106 | ||
| ANO1 | 0.0465 | 0.00153 | ||
| MFN1 | 0.0094 | 0.0081 | ||
| PSMD2 | 8.94e-04 | 0.00994 | ||
| PIK3CA | 0.0449 | 0.0145 | ||
| TRMT12 | 0.0422 | 0.0346 | ||
| IGF2BP2 | 0.0277 | 0.04 | ||
| ZNF12 | 0.0426 | 0.044 | ||
| IL1RAP, RYK, MFN1 and PSMD2 (Combination) | 5.25e-04 | 5.00e-04 | ||
| 2 | Stage I-II* | TWISTNB | 0.00166 | |
| KLHL13 | 0.00173 | |||
| UBE2Q1 | 0.0037 | |||
| WBP11 | 0.0108 | |||
| ATP1B1 | 0.0235 | |||
| ZNF687 | 0.0253 | |||
| FXR1 | 0.0453 | |||
| PFN2 | 0.0453 | |||
| EPS8 | 0.0453 | |||
| WDR53 | 0.0453 | |||
| SDE2 | 0.0465 | |||
| TERF1 | 0.0453 | |||
| TWISTNB, KLHL13, UBE2Q1 and WBP11(combination) | 8.47e-04 | |||
| 3 | Stage III-IV | IL1RAP | 0.00396 | 1.32e-07 |
| ANO1 | 0.0186 | 5.25e-04 | ||
| RYK | 0.0106 | 0.00175 | ||
| AP2M1 | 0.00474 | 0.00356 | ||
| MFN1 | 0.00881 | 0.0148 | ||
| PSMD2 | 0.0012 | 0.0153 | ||
| TRMT12 | 0.0353 | 0.0275 | ||
| IGF2BP2 | 0.0207 | 0.0429 | ||
| IL1RAP, ANO1, RYK, AP2M1, MFN1 and PSMD2 (combination) | 0.0016 | 0.00512 | ||
| 4 | PNI + | AP2M1 | 0.0133 | 0.0259 |
| 5 | ALI + | RYK | 0.00245 | 0.00717 |
| IL1RAP | 0.0333 | 0.0125 | ||
| AP2M1 | 0.0359 | 0.035 | ||
| RYK and IL1RAP (combination) | 6.79e-04 | 0.0209 | ||
| 6 | Node+ ECS+ | STK3 | 0.00163 | 0.00106 |
| TMEM267 | 0.00298 | 0.00121 | ||
| CLPTM1L | 0.0489 | 0.0118 | ||
| PSMD2 | 0.00504 | 0.0175 | ||
| STK3, TMEM267 and PSMD2 (combination) | 6.11e-04 | 0.00401 | ||
| 7 | Node+ ECS- | VKORC1L1 | 0.0323 | 0.00545 |
*In stage I-II all the genes were associated with only overall survival,
#genes were sorted based on DFS.