Table 3.

Association between DRN (autoreceptor) and heteroreceptor 5-HT_1A BP_ND representing correlation coefficients R and regression slopes β for each group separately

Region	Anatomical ROI			Functional ROI
	Healthy controls	Patients		Patients
		Before SSRI	After SSRI	Before SSRI	After SSRI
Correlation coefficient R
Amygdala
Right	0.56***	0.5*	0.79***	0.46*	0.88***
Left	0.55***	0.51*	0.73**	0.49*	0.9***
Hippocampus
Right	0.45**	0.53*	0.73**	0.47*	0.82***
Left	0.47**	0.49*	0.7**	0.5*	0.85***
Regression slope β
Amygdala
Right	0.99***	0.87*	1.91***	0.8*	2.74***
Left	1.07***	0.9*	1.5**	1*	2.61***
Hippocampus
Right	0.86**	1.04*	2**	0.78*	2.5***
Left	0.97**	1.23*	1.92**	1*	2.7***

ROIs were defined (1) anatomically (Stein et al., 2008) [ROI atlas-based (Tzourio-Mazoyer et al., 2002)] and (2) functionally comprising clusters with significant differences between patients before and after treatment** (see Fig. 2a,b).

*p < 0.05; **p < 0.01; ***p < 0.001, all parameters survive correction for multiple comparisons (p < 0.05, FDR).