Table 4.

Group differences in the association between the DRN and heteroreceptor 5-HT_1A BP_ND

Region	Functional ROI peak voxel
	Patients after versus before SSRI			Patients after SSRI versus healthy controls
	MNI (mm)	t value	Z value	MNI (mm)	t value	Z value
Amygdala
Right	12, 0, −20	4.98***	2.78**#	16, 0, −20	5.78***#	3.38***#
Left	−16, −2, −22	2.76**	2.62**#	−18, −2, −22	3.01**	2.61**#
Hippocampus
Right	18, −16, −14	4.39***	2.2*	18, −14, −14	6.45***#	3.9***#
Left	−18, −24, −16	3.82***	2.04*	−18, −24, −16	4.46***	3.09**#

ROIs were defined functionally as clusters where patients showed significantly steeper regression slopes after treatment** (see Fig. 2). t and Z values of these functional ROIs represent peak differences in the regression slope β and correlation coefficient R, respectively, when comparing patients before and after escitalopram medication (see Fig. 2a,b) as well as between treated patients and healthy subjects (see Fig. 2c,d).

*p < 0.05; **p < 0.01; ***p < 0.001; ^#withstanding correction for multiple comparisons (FDR and Bonferroni-Holm for t and Z values, respectively).