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. 2010 Dec 8;30(49):16523–16535. doi: 10.1523/JNEUROSCI.1109-10.2010

Figure 5.

Figure 5.

Effects of 130 Hz stimulation of the PF nucleus on HPDs. A, Intensity thresholds according to stimulation mode: ipsilateral, contralateral, or bilateral stimulations (n = 9, 9, and 4 mice respectively; *p < 0.05, Wilcoxon test, compared with ipsilateral stimulation values; #p < 0.05, Wilcoxon test, compared with antiepileptic threshold values). B, Site specificity of ipsilateral 130 Hz stimulation. Intensity thresholds according to electrode tip localization, inside versus outside the boundaries of the PF nucleus (n = 9 mice inside; n = 6 mice outside; *p < 0.05, Mann–Whitney test, compared with thresholds obtained with stimulations applied within the PF nucleus). C, Time–frequency chart of power averaged over hippocampal and cortical derivations and over 24 hippocampal HPDs interrupted by 130 Hz stimulation of the PF nucleus. Before averaging, the power was frequency normalized according to interictal activity. The color scale indicates the increase (shades of red) or decrease (shades of blue) of power expressed in standard deviations of the interictal activity. D, Mouse's brain coronal sections showing histological reconstruction of the electrode tip localization inside the PF nucleus (black dots) and outside the boundaries of the PF nucleus (open triangles). IA, Interaural; ml, medial lemniscus; fr, fasciculus retroflexus.