Table 1.
Subject | Age at diagnosis, y | MIPI risk | Best response | PFS, mo | MRD assay time point | |||
---|---|---|---|---|---|---|---|---|
Time on study, mo | Maintenance regimen | MRD result | MRD interpretation | |||||
1 | 51 | Low | CR | 69+ | 51 | LR | <10−6 | Undetectable |
2 | 55 | Intermediate | CR | 65+ | 49 | LR | <10−6 | Undetectable |
3 | 53 | Low | CR | 65+ | 51 | LR | <10−6 | Undetectable |
4 | 65 | Intermediate | CR | 62+ | 42 | None* | <10−6 | Undetectable |
5 | 66 | High | CR | 62+ | 62 | R | 3.0 × 10−6 | Detectable |
6 | 73 | High | PR | 61+ | 46 | R | 1.2 × 10−5 | Detectable |
7 | 56 | Intermediate | CR | 56+ | 43 | None* | <10−6 | Undetectable |
8 | 80 | High | CR | 53+ | 35 | R | <10−6 | Undetectable |
9 | 60 | Low | CR | 45+ | 42 | R | <10−6 | Undetectable |
10 | 82 | High | CR | 46+ | 46 | R | <10−6 | Undetectable |
R, rituximab.
Two subjects opted to discontinue study treatment after 3 years.