Figure 4. Evolutionary signatures in cluster O contain some molecular features that are typically associated with IDRs as well as some that are not.

(A) Pattern of evolutionary signatures in cluster O. (B) Example disordered region from cluster O, Ccr4, with a subset of highlighted molecular features compared between its real set of orthologs and an example set of simulated orthologous IDRs. Species included in phylogeny in order from top to bottom are S. cerevisiae, Saccharomyces mikatae, Saccharomyces kudriavzevii, Saccharomyces uvarum, Candida glabrata, Kazachstania naganishii, Naumovozyma castellii, Naumovozyma dairenensis, Tetrapisispora blattae, Tetrapisispora phaffii, Vanderwaltozyma polyspora, Zygosaccharomyces rouxii, Torulaspora delbrueckii, Kluyveromyces lactis, Eremothecium (Ashbya) cymbalariae, Lachancea waltii.