(A) Pattern of evolutionary signatures in cluster D. (B) Example disordered region from cluster D, Srs2, with a subset of highlighted molecular features compared between its real set of orthologs and an example set of simulated orthologous IDRs. Species included in phylogeny in order from top to bottom are S. cerevisiae, S. mikatae, S. kudriavzevii, S. uvarum, C. glabrata, Kazachstania africana, K. naganishii, N. castellii, N. dairenensis, T. phaffii, Z. rouxii, T. delbrueckii, K. lactis, Eremothecium (Ashbya) gossypii, E. cymbalariae, Lachancea kluyveri, Lachancea thermotolerans, L. waltii.