Figure 3. Placental morphology is regulated by both fetal and trophoblast p110α.

(A) Het-P, (B) Het-F and (C) Het-U placental morphology on day 19 of pregnancy as determined by stereology. *p<0.05, **p<0.01, and ***p<0.001 versus WT, unpaired t test. Data presented as means ± SEM. Scale bar for hematoxylin and eosin-stained placental cross-sections is 500 μm. 6–10 placentas were assessed for each genotype for labyrinthine zone (Lz) volume and 4–5 analysed for Lz morphology.

Figure 3—figure supplement 1. Junctional zone volume is not modified by fetal and/or trophoblast loss of p110α.

Placental junctional zone volume on day 19 of pregnancy in Het-P (A), Het-F (B) and Het-U (C). n ≥ 6 placentas were assessed for each genotype. Data are presented as means ± SEM.