Figure 4. Placental nutrient transfer is adaptively increased in response to fetal and/or trophoblast loss of p110α.

(A–F) The capacity of the placenta to transport ³H-methyl-D glucose (MeG) and ¹⁴C-amino isobutyric acid (MeAIB) relative to surface area available or to fetal weight (D–F) on day 19 of pregnancy for Het-P (n = 15) (A, D), Het-F (n = 24) (B, E) and Het-U (n = 16) (C, F), expressed as a ratio of their respective WT control values (denoted as a dotted line, n = 21, 18 and 21, respectively). DPM = disintegrations per minute. *p<0.05 and ***p<0.001 versus WT, unpaired t test. Data presented as means ± SEM.

Figure 4—figure supplement 1. Total solute accumulation in response to fetal and/or trophoblast loss of p110α.

The accumulation of ³H-methyl-D glucose (MeG) and ¹⁴C-amino isobutyric acid (MeAIB) on day 19 of pregnancy for Het-P (n = 15) (A, D), Het-F (n = 24) (B, E) and Het-U (n = 16) (C, F) with their respective WT control values (n = 21, 18 and 21, respectively). DPM = disintegrations per minute. Data presented as means ± SEM.