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. 2019 Jun 26;8:e45282. doi: 10.7554/eLife.45282

Figure 5. Retaining trophoblast p110α is critical for the ability of the placenta to increase amino acid transport.

MeG and MeAIB transport relative to surface area available (A) or to fetal weight (B) on day 19 of pregnancy in Hom-P (n = 16), expressed as a ratio of Het-U control values (denoted as a dotted line, n = 16). DPM = disintegrations per minute. *p<0.05 versus Het-U, unpaired t test.

Figure 5—source data 1. The effect of deleting the remaining p110α from trophoblast in Hom-P on placental transport capacity relative to WT and Het-P.
Placental transport of 3H-methyl-D glucose (MeG) and 14C-amino isobutyric acid (MeAIB) relative to surface area available or to fetal weight on day 19 of pregnancy is shown as a ratio of WT values. Hom-P * versus WT or † versus Het-P. *p<0.05, †p<0.05 and †††p<0.001, unpaired t test. DPM = disintegrations per minute. Data are from n ≥ 15 and presented as means ± SEM.
elife-45282-fig5-data1.docx (14.9KB, docx)
DOI: 10.7554/eLife.45282.016

Figure 5.

Figure 5—figure supplement 1. Total solute accumulation in Het-U versus Hom-P.

Figure 5—figure supplement 1.

MeG and MeAIB accumulation on day 19 of pregnancy in Het-U control values (n = 16) and Hom-P (n = 16). DPM = disintegrations per minute. *p<0.05 versus Het-U, unpaired t test.