Table 1. Deleting the remaining p110α from fetal compartment of the conceptus results in fetal lethality in Hom-F mutants between days 11 and 12 of pregnancy.
Frequency of viable fetuses in a litter per gestational age are displayed, with the number of litters in parentheses.
Table 1—source data 1. Deleting the remaining p110α from the trophoblast in Hom-P does not affect fetal viability at day 19 of pregnancy.
Frequency of viable fetuses in a litter are displayed, with data from n = 15 litters. Offspring genotypes were determined by conventional PCR, and in the case of Cyp19Cre mutants, additionally by qRT-PCR to identify those with a sufficient level of Pik3ca deletion (frequency is in parentheses). When the cut off for Pik3ca deletion in the placenta using qRT-PCR was applied (<65% for Het-P and <30% for Hom-P), the frequency of Cyp19Cre mutants was ~50% less.
elife-45282-table1-data1.docx (13.2KB, docx)
DOI: 10.7554/eLife.45282.005
| WT | Het-F | Het-U | Hom-F | |
|---|---|---|---|---|
| D10 (5) | 23% | 26% | 34% | 17% |
| D11 (6) | 35% | 23% | 29% | 13% |
| D12 (2) | 50% | 25% | 25% | 0% |
| D13 (3) | 39% | 33% | 28% | 0% |