Table 2. Deleting the remaining p110α from the trophoblast reduces fetal weight but does not alter placental growth on day 19 of pregnancy, in Hom-P relative to Het-U controls.
Conceptus weights are from n ≥ 18, Lz and Jz volume from n ≥ 6 and Lz morphology from n ≥ 4 per genotype. Data are presented as means ± SEM. * versus Het-U, p<0.05, unpaired t test.
Table 2—source data 1. The effect of deleting the remaining p110α from the trophoblast in Hom-P on feto-placental growth relative to WT and Het-P.
Hom-P * versus WT or † versus Het-P. *p<0.05 and ***p<0.001, †p<0.05 and †††p<0.001, unpaired t test. Conceptus weights are from n ≥ 15, Lz and Jz volume from n ≥ 6 and Lz morphology from n ≥ 4 per genotype on day 19 of pregnancy. Data are presented as means ± SEM.
elife-45282-table2-data1.docx (14.1KB, docx)
DOI: 10.7554/eLife.45282.007
| Het-U | Hom-P | |
|---|---|---|
| Fetus (mg) | 1075 ± 31 | 994 ± 22* |
| Placenta (mg) | 84 ± 3 | 89 ± 3 |
| Labyrinthine zone (mm3) | 38 ± 3 | 36 ± 2 |
| Junctional zone (mm3) | 31 ± 3 | 30 ± 2 |
| Maternal blood spaces (mm3) | 13 ± 3 | 11 ± 1 |
| Trophoblast (mm3) | 20 ± 1 | 22 ± 2 |
| Fetal capillaries (mm3) | 3 ± 1 | 4 ± 1 |
| Barrier thickness (μm) | 4.0 ± 0.2 | 3.9 ± 0.1 |
| Surface area (mm2) | 11 ± 1 | 10 ± 1 |