Table 2.
Comparison of demographic and clinical characteristics between neuro-asymptomatic subgroups and symptomatic participants using ANOVA or chi-squared tests. Key: NA: Neuro-asymptomatic (ADC=0); NS: Neuro-symptomatic (ADC>0); dVL: Detectable Viral Load (plasma HIV RNA ≥ 400 cp/mL); uVL: Undetectable Viral Load (plasma HIV RNA <400 cp/mL); SD: Standard Deviation.
| NS N=51 |
NA N=92 |
P-Value | NS or dVL aN=66 |
NA-uVL N=76 |
P-Value | |
|---|---|---|---|---|---|---|
| Continuous Variables | Mean (SD) | ANOVA | Mean (SD) | ANOVA | ||
| Age (yrs) | 50.0 (8.0) | 47.0 (9.6) | 0.066 | 50.2 (8.3) | 46.3 (9.5) | 0.011* |
| HIV Duration (yrs) | 12.9 (6.5) | 10.6 (7.2) | 0.068 | 13.1 (6.4) | 9.8 (7.1) | 0.004* |
| cART Duration (yrs) | 5.1 (4.9) | 4.7 (4.0) | 0.376 | 5.1 (4.52) | 4.7 (4.1) | 0.508 |
| CPE Score | 8.1 (3.3) bN=49 | 8.1 (2.7) | 0.977 | 7.8 (3.24) bN=64 | 8.3 (2.6) | 0.298 |
| Nadir CD4+ (cells/mm3) | 67.8 (62.5) | 57.1 (56.7) | 0.297 | 65.0 (60.3) | 57.6 (58.0) | 0.456 |
| CD4+ Count (cells/mm3) | 387.0 (205.8) | 370.2 (197.3) bN=91 | 0.632 | 372.8 (211.5) | 379.3 (190.6) | 0.848 |
| Inter-Scan Time Interval (yrs) | 1.1 (0.5) | 1.0 (0.6) | 0.613 | 1.0 (0.5) | 1.1 (0.5) | 0.855 |
| Categorical Variables | % (N) | χ2-Test | % (N) | χ2-Test | ||
| Sex (male) | 78.4% (40) | 84.8% (78) | 0.338 | 80.3% (53) | 84.2% (64) | 0.542 |
| Education (≤ high school) | 47.1% (24) | 41.3% (38) | 0.506 | 42.4% (28) | 44.7% (34) | 0.782 |
| Race/Ethnicity (Caucasian) | 54.9% (28) | 75.0% (69) | 0.014* | 53.0% (35) | 80.3% (61) | 0.001* |
| Suppressed CD4+ (≤ 350 cells/mm3) | 49.0% (25) | 53.9% (49) bN=91 | 0.581 | 53.0% (35) | 51.3% (39) | 0.838 |
| Detectable Plasma HIV RNA (≥400 copies/mL) | 35.3% (18) | 16.5% (15) bN=91 | 0.011* | 50.0% (33) | 0% (0) | 1.98×10−12* |
*
P ≤ 0.05
a
N = 18 are both NS with dVL
b
Total N with available data are noted