Table 4.

The IC₅₀ values for latonduine derivatives HL¹–HL⁴ and their copper(II) complexes 1–4 , as well as for copper(II) complexes with paullones 5, 6. *Selectivity factors (SFs) for Colo 205 and Colo 320 cancer cell lines over non-cancerous MRC-5 cells. SF₍₂₀₅₎ = IC₅₀ MRC-5/IC₅₀ Colo 205, SF₍₃₂₀₎ = IC₅₀ MRC-5/IC₅₀ Colo 320.

	IC50 (μM),a 72 h
	Colo 205	Colo 320	MRC-5	SF(205)*	SF(320)*
HL1	0.266 ± 0.012	0.294 ± 0.005	1.522 ± 0.547	6	5
HL2	0.189 ± 0.040	0.051 ± 0.012	2.312 ± 0.032	12	45
HL3	0.037 ± 0.004	0.042 ± 0.001	0.127 ± 0.004	3	3
HL4	0.017 ± 0.002	0.018 ± 0.005	1.257 ± 0.463	74	70
1	0.346 ± 0.008	0.315 ± 0.023	0.461 ± 0.069	-	-
2	0.556 ± 0.028	0.104 ± 0.002	0.378 ± 0.004	-	4
3	0.017 ± 0.001	0.020 ± 0.001	0.162 ± 0.009	10	8
4	0.007 ± 0.001	0.015 ± 0.002	0.201 ± 0.001	29	13
5	1.704 ± 0.218	0.413 ± 0.044	0.152 ± 0.001	-	-
6	0.380 ± 0.032	0.120 ± 0.007	0.061 ± 0.003	-	-
Cisplatin	31.94 ± 2.17	4.81 ± 0.68	12.41 ± 0.367	-	3