Table 1.

Amino acid diversity in each position in V3 region and numbers of each residue in the predicted R5 and X4/R5X4 tropic viruses.

HXB2

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

22

23

24

25

26

–

27

28

29

30

31

32

33

34

35

36

C

T

R

P

N

N

N

T

R

K

R

I

R

I

Q

R

G

P

G

R

A

F

V

T

I

G

–

K

I

G

N

M

R

Q

A

H

C

R5 tropic (n = 97)

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

22

23

24

25

26

27

28

29

30

31

32

33

34

35

36

C96

T94

R97

P97

S92

N95

N97

T92

R96

T82

S92

I74

R31

I75

–

–

G96

P96

G97

Q57

A34

F89

Y89

R80

T92

G96

D80

I96

I76

G97

D85

I94

R95

Q65

A97

Y84

C97

S1

I2

F2

T2

V2

I1

K6

G5

T12

S20

M17

A1

L1

R25

T31

Y4

F7

K7

I4

E1

E14

V1

T15

N12

P1

K2

K22

F11

S1

Y1

I1

E4

V8

N18

L3

K7

M15

L2

I1

G4

N1

A3

V3

V1

S4

H2

N1

Q1

Q3

M2

T14

F2

G3

V15

W1

S4

K2

T1

R3

A1

K1

S1

L1

H7

S3

S1

I1

A1

R1

L1

G1

P4

A2

I1

Q1

E1

Q1

M1

G1

A1

X4/R5X4 tropic (n = 28)

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

22

23

24

25

26

27

28

29

30

31

32

33

34

35

36

C27

T26

R28

P28

S17

N25

N27

T20

R27

T21

S25

T11

R18

I24

–

–

G28

P28

G26

Q18

V14

F24

Y23

R20

T27

G26

D16

I25

I20

G28

D23

I26

R27

K21

A28

Y23

C27

S1

I1

F4

S1

T1

I8

G1

K4

G2

I11

S3

T1

V1

R7

M6

L2

H2

K6

R1

E2

E5

T1

T7

N4

L1

G1

Q7

H3

H1

A1

Y4

T1

I3

R1

M2

T2

F1

A1

S1

A5

Y1

F2

G2

A4

L1

G1

V1

E1

F1

T1

I1

F2

H2

L1

G1

F1

I1

S1

S2

S1

N1

L1

G1

M1

K1

T1

G1

C1

V1

N1

K1

Amino acids were numbered according to the HXB2 V3 sequence. The number in the superscript of an amino acid residue represented the number of the residue in this position; statistically different substitutions were in bold and in box. R5, CCR5; R5X4, CCR5 and CXCR4; X4, CXCR4.