Table 2 -.

Multivariable Cox Regression Model Predicting HCC Recurrence Survival

Variable	Hazard Ratio	95% Confidence Interval	P value
Age at transplant (per 5 years)	1.06	(1.01 – 1.11)	0.03*
MELD score (per 5 points)	1.07	(1.02 – 1.13)	<0.01*
Maximum pre-transplant AFP category (ng/mL; ref ≤20)
21–99	1.25	(1.04 – 1.50)	0.02*
100–499	1.45	(1.20 – 1.76)	<0.001*
≥500	1.61	(1.28 – 2.02)	<0.001*
Time to HCC recurrence (per month)	0.99	(0.99 – 1.00)	0.12
Time to HCC recurrence (TVC)	1.00	(1.00 – 1.00)	<0.01*

MELD = model for end-stage liver disease, AFP = alpha fetoprotein, HCC = hepatocellular carcinoma, TVC = time-varying covariate

^*p < 0.05

^**Sex and transplant region were significant on univariate analysis but not retained in multivariable models