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Microglia depletion results in fatal encephalitis. Microglia-depleted mice and microglia-competent mice infected with 4×104, plaque forming units (PFU) of Theiler’s murine encephalomyelitis virus (TMEV) were observed for 19 days post infection (p.i.). Mortality represented as percent daily survival of animals in comparison to day 0 (n = 10 mice per group at the start of the experiment; p < 0.0001; log-rank test).
