Table 2.
Uni- and multivariable Cox regression on the derivation cohort.
| Univariable | Multivariable Model 1 | Multivariable Model 2 | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | p−value | HR (95% CI) | p−value | HR (95% CI) | p–value | |
| Age, years | 1.07 (1.05–1.08) | <0.001 | 1.06 (1.04–1.08) | <0.001 | 1.05 (1.03–1.07) | <0.001 |
| BMI, kg/m2 | 1.01 (0.97–1.05) | 0.734 | ||||
| Male | 1.17 (0.83–1.65) | 0.369 | 1.09 (0.76–1.57) | 0.622 | 0.98 (0.68–1.40) | 0.902 |
| Chest pain symptoms* | 0.134 | |||||
| Non–cardiac | 0.48 (0.56–0.90) | – | ||||
| Atypical | 0.89 (0.60–1.31) | – | ||||
| Typical | 1.04 (0.60–1.79) | – | ||||
| Cardiovascular risk factors | ||||||
| Diabetes mellitus | 1.44 (1.01–2.06) | 0.046 | 1.39 (0.85–2.03) | 0.086 | 1.27 (0.88–1.88) | 0.193 |
| Hypertension | 1.46 (1.03–2.06) | 0.033 | 0.98 (0.68–1.42) | 0.928 | 0.94 (0.65–1.35) | 0.722 |
| Hypercholesterolemia | 0.80 (0.55–1.18) | 0.263 | 0.62 (0.41–0.92) | 0.019 | 0.59 (0.39–0.89) | 0.011 |
| Family history of CAD | 0.55 (0.38–0.81) | 0.002 | 0.78 (0.46–1.01) | 0.054 | 0.66 (0.45–0.98) | 0.038 |
| Currently smoking | 1.70 (1.15–2.50) | 0.008 | 2.01 (1.39–3.13) | <0.001 | 1.90 (1.26–2.86) | 0.002 |
| CAD–RADS† | ||||||
| CAD–RADS 2–3 | 3.19 (2.00–5.07) | <0.001 | 1.95 (1.19–3.20) | 0.008 | – | |
| CAD–RADS 4–5 | 6.28 (3.26–12.11) | <0.001 | 2.68 (1.30–5.53) | 0.007 | – | |
| Comprehensive CTA score‡ | ||||||
| Score 6–20 | 3.71 (2.44–5.62 | <0.001 | – | 2.69 (1.72–4.22) | <0.001 | |
| Score >20 | 8.00 (4.88–13.13) | <0.001 | – | 4.64 (2.63–8.16) | <0.001 | |
*
Asymptomatic is the reference
†
CAD-RADS 0–1 is the reference
‡
Comprehensive CTA score 0–5 is the reference
CAD-RADS, Coronary Artery Disease – Reporting and D ata System