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. 2019 Jul 16;9:10310. doi: 10.1038/s41598-019-46639-1

Figure 6.

Figure 6

Evaluation of thymosin α-1 as F508del-CFTR rescue maneuver on human CF primary bronchial epithelia (HBE). (A) Representative traces obtained from Ussing chamber experiments on HBE generated from a homozygous F508del patient (donor code CF-BEX05), after incubation for 24-hour with vehicle, Tα-1 (100 ng/ml, pre-diluted in acqueous buffer), VX-809 (3 μM). (B) Dot plot reporting CFTR-mediated (top) and CaCC-mediated (bottom) currents measured during the experiments depicted in (A). Mean values ± SD are shown (n = 4). **P < 0.01 versus negative control by ANOVA.