Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 16;10:3060. doi: 10.1038/s41467-019-11005-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — Transcriptomic responses to S. pneumoniae in vitro are influenced by adhesion and micro-invasion. a The total number of Detroit 562 epithelial genes upregulated following exposure to 6B, 23F, TIGR4 and TIGR4-dPly pneumococci, compared with non-infected samples. N = 3 independent experiments with replicates. Genes with an FDR <0.05 were considered for further analysis. The matrix shows intersections for the four strains, sorted by size. Dark circles in the matrix indicate sets that are part of the intersection. b Bubble heatmap showing the results of transcriptional factor analysis in Opossum for each strain. Transcriptional factors are ordered by family and then sorted by number of genes in the database. The colour represents the log2 z-scores (a continuum from blue (lowest values) to red (highest values)) and the size shows the number of genes annotated to the particular pathway. c Bubble heatmap showing the results of reactome pathway analysis for upregulated genes in each strain compared with non-infected cells. Pathways were clustered in 20 groups using K-means on Jaccard index and the biggest pathway for each group was selected for representative annotation of each cluster. Individual pathways within clusters are shown in Supplementary Fig. 8. The colour represents the log2 z-scores (a continuum from blue (lowest values) and red (highest values)) and the size shows the number of genes annotated to each pathway. d Selected bubble heatmap clusters representing the individual pathways within each cluster from (c)