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. 2019 Jul 16;10:3126. doi: 10.1038/s41467-019-11004-3

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© The Author(s) 2019, corrected publication 2023

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Fig. 2 — The predicted activity of liver-enriched transcription factors is defective in AH patients. a, b Transcription factor transcriptomic footprint inferred using Ingenuity Pathway Analysis (IPA) and Opossum analyses. Top differentially expressed (DE) genes between a normal livers and early ASH and b between early ASH and AH patients were the input for these analyses. Blue/Red indicates predicted activation/inhibition or motif enrichment in top 2000 downregulated/upregulated DE genes. c Selected target genes of PPARγ identified by IPA analysis. d Selected target genes of HNF4α identified by IPA analysis. Fold Changes (FC) in Normal vs Early ASH and between Early ASH and AH are presented. All genes in g and h had a FDR <10⁻⁶ in DE analysis