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. 2019 Jul 16;10:3126. doi: 10.1038/s41467-019-11004-3

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© The Author(s) 2019, corrected publication 2023

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Fig. 4 — TGFβ1 is the main upstream regulator of transcriptomic reprogramming in ALD. a Treemap of the top predicted activated growth factors, cytokines and chemicals as detected by IPA. Color and box areas are related to p-values, indicated in top-right color-scale. Most significant hits (P < 10⁻⁴) are shown. b, c mRNA abundance in transcripts per million (tpm) from normal livers, AH livers and livers of non-alcohol-related chronic disease of b TGFβ1, TGFβRI, and TGFβRII and c Amphiregulin (AREG). For box-and-whisker plots: perimeters, 25th–75th percentile; midline, median; whiskers, minimum to maximum values; individual data points are represented. Gene expression levels are presented in transcripts per million reads (tpm)