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. 2019 Jul 16;10:3126. doi: 10.1038/s41467-019-11004-3

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© The Author(s) 2019, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — miR122 levels and miR122 predicted downregulation in AH patients. a RNA levels of hpri-miR122 in our cohort b levels of Grainyhead Like Transcription Factor 2 (GRHL2) in our cohort c correlation of GRH2L2 and MIR122 levels. R and p value (Kendall) are presented. d Results of miRNA predicted activity by means of IPA Upstream Regulator analysis when comparing early ASH vs AH. Top 8 miRNA are presented. e Venn diagram of the overlap between HNF4A and MIR122 targets among the differentially expressed genes in the comparison between early ASH and AH. f Box plot of most 10 validated miR122 targets (miRTarBase database) in our cohort. Box-and-whisker plots indicate 25th–75th percentile; midline, median; whiskers, minimum to maximum values; individual data points are represented. In bold, those genes that reached FDR < 10⁻⁶ level of significance in DESeq2 differential expression analysis between early ASH and AH. For box-and-whisker plots: perimeters, 25th–75th percentile; midline, median. Gene expression levels are presented in transcripts per million reads (tpm)