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. 2019 Jul 16;9:10260. doi: 10.1038/s41598-019-46727-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of the gene expressions by qRT-PCR in human thyroid tumors. (A) HMGR gene expression, (B) CYP7B1 gene expression, (C) LXR gene expression, (D) CYP27A1 gene expression. The patient cohort was divided into the following groups: BTT (n = 32), low/intermediate-risk PTC (n = 37), high-risk PTC (n = 12), and PDTC/ATC (n = 7). Endogenous expression of the GADPH gene was used to normalize the data, and BTT was used as calibrator tissue. Statistical analysis: ANOVA test plus Tukey’s post-test (*p < 0.05, **p < 0.01, ***p < 0.001).