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. 2019 Jul 16;9:10260. doi: 10.1038/s41598-019-46727-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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27-hydroxycholesterol (27-HC) content and their relationship with the CYP7B1 gene expression in thyroid tumor tissue extracts. (A) The analysis of 27-HC was measured in 82 patients (n = 97 thyroid tissue samples) corresponding to BTT (n = 40), low/intermediate-risk PTC (n = 30), high-risk PTC (n = 18) and PDTC/ATC (n = 9). The results represent the mean ± SD of the measurements of individual thyroid tissue. (ANOVA) using the Kruskal–Wallis test and Dunn’s post-test (***p < 0.001). (B) A correlation analysis was done in 73 samples in which 27-HC and CYP7B1 expression were analyzed in the same sample (27 BTT, 29 low/intermediate-risk PTC, 11 high-risk PTC and 6 PDTC/ATC samples). The graph illustrates the negative correlation between the CYP7B1 gene expression (2^−ΔΔCT) and 27-hydroxycholesterol (27-HC) levels. CYP7B1 gene expression is showed log-transformed. R (−0.428), Pearson’s correlation coefficient; p ≤ 0.001.