Table 1.

Estimated rate constants for 2-state binding of substrates and human P450s from previous literature

P450	Substrate	Rate constants		Reference
		kon	koff
2A6	Coumarin	2.7 × 106 m−1 s−1	5.7 s−1	7
	7-Hydroxycoumarin	2.0 × 106 m−1 s−1	6.8 s−1
4A11	Lauric acid	2.0 × 106 m−1 s−1	4.0 s−1	27
19A1	Androstenedione	2.5 × 106 m−1 s−1	1.4 s−1	28
	19-OH androstenedione	2.0 × 107 m−1 s−1	240 s−1
	19-Formyl androstenedione	2.5 × 106 m−1 s−1	300 s−1
21A2	Progesterone	2.4 × 107 m−1 s−1	0.24 s−1	29
	17α-OH progesterone	2.2 × 106 m−1 s−1	0.66 s−1
27C1	All-trans-retinol	7.2 × 105 m−1 s−1	0.42 s−1	30