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. 2019 Jul 10;10:1599. doi: 10.3389/fimmu.2019.01599

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Copyright © 2019 Nijmeijer and Geijtenbeek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Opposing selection pressures during transmitted founder HIV-1 transmission at mucosal surfaces. The within-host evolution creates a selection bias that leads to either viral restriction or establishes a new infection. Transmitted founder viruses are able to escape host restriction and are therefore responsible for establishing productive infection. TF HIV-1, transmitted founder HIV-1; DCs, dendritic cells; IFN, Interferon; SEVI, semen-derived enhancer of virus infectivity.