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. 2019 Jul 16;9:10278. doi: 10.1038/s41598-019-46531-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IGF1R inhibitors prevent FGF2-stimulated transformation whereas efficacy of HMG-CoA reductase inhibitors varies. (A) Fluvastatin (Fluv), simvastatin (Sim), rosuvastatin (Rosu), PPP, and NVP-ADW742 (NVP) significantly attenuated FGF2 (5 ng/mL)-stimulated transformation of JB6 P⁺ cells (2,000 cells/well) at 5.0 µM. Colonies were counted via automated counting using the Cytation 3 imaging reader from Biotek using Gen5 3.04 software. Seven pictures were taken every 100 microns and superimposed together by the zprojection function. (B) Fluvastatin (Fluv), rosuvastatin (Rosu), atorvastatin (Ator), and NVP-ADW742 (NVP) significantly attenuated FGF2 (30 ng/mL)-stimulated transformation of MCF-10A cells (1,000 cells/well) at 0.5 and 2.5 µM. Simvastatin (Sim) was significant at 2.5 µM. Each treatment group had three replicates and analyzed by one-way ANOVA with multiple comparisons (*p < 0.05; **p < 0.01).