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. 2019 Jul 16;9:10319. doi: 10.1038/s41598-019-46643-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tissue MRS differentiations among LuCa types and stages. After pathology calibrations for the tissue MRS spectral data, various LuCa types and stage groups were compared with two-sided Student’s t-test (for normal spectral region distributions) or Mann-Whitney-Wilcoxon test (for non-normal spectral region distributions). “Increase” indicates that the values are higher in the lower group compared to the upper group; “Decrease”, indicates the opposite. For instance, the first blue square in the table shows that the group of SCC samples presented significantly lower spectral intensity in the glycerophosphocholine and tyrosine region. See text for significance notation details, and see Supplementary Table S1 for sample numbers in each group. Abbreviations: Ala, alanine; Glu, glutamate; GPC, glycerophosphocholine; Lip: lipids; PC, principal component; St, stage; Tyr, tyrosine; Val, valine.