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. 2019 Jul 16;9:10276. doi: 10.1038/s41598-019-46659-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship between TRA2B transcript levels and hnRNPA1 or hnRNPU mRNA levels in colon cancer. (a–d) Amounts of hnRNPA1, hnRNPU or TRA2β1 and TRA2β4 were measured by RT-qPCR in 24 patients with colon cancer. ACTB mRNA was used as an internal control for normalization. The correlations between hnRNPA1 and TRA2β1 (a), hnRNPA1 and TRA2β4 (b), hnRNPU and TRA2β1 (c), or hnRNPU and TRA2β4 (d) were analyzed by Pearson’s correlation analysis. (e) Comparison of mRNA levels of hnRNPA1, hnRNPU or TRA2β1 and TRA2β4 in normal colon cell line (HCEC) and colon cancer cell line (HCT116). (f) Comparison of protein levels of Tra2β, hnRNPA1, and hnRNPU in HCEC and HCT116. (g) Effects of hnRNPA1 or hnRNPU knockdown on growth of HCT116 cells. After treatment of HCT116 cells with control, hnRNPA1, or hnRNPU siRNA, growth of these cells was monitored by counting the number of cells using CellTiter-Glo Luminescent Cell Viability Assay (Promega). Values are means ± SD, n = 4. *Significantly different compared with control siRNA-treated cells (p < 0.05) by two-tailed Student’s t-test.