Table 3.
Results of Psychometric Analysis of Real-World Daily eDiary Data
| Parameter | Itch NRS[a] | Skin Pain NRS[a] |
|---|---|---|
| Test-retest reliability[b] (n = 31) | ||
| Week 1 to Week 2 Average | 0.95 | 0.97 |
| Day 7 to Day 14 | 0.94 | 0.91 |
| Concurrent validity[c] | ||
| POEM (Week 1; n = 74) | 0.80 | 0.75 |
| POEM (Week 2; n = 66) | 0.84 | 0.77 |
| PGIS (Week 1; n = 55) | 0.72 | 0.68 |
| PGIS (Week 2; n = 42) | 0.74 | 0.65 |
| DLQI Summary Score (Adult population; n = 33–53) | 0.59–0.74 | 0.57–0.73 |
| CDLQI Summary Score (Adolescent population; n = 9–19) | 0.76–0.89 | 0.77–0.91 |
| Responsiveness[d] | ||
| Week 1 to Week 2 Average | p = 0.02 | p = 0.003 |
| Decline | ES = 1.21 (n = 5) | ES = 1.09 (n = 5) |
| No Decline | ES = 0.41 (n = 24) | ES = 0.34 (n = 39) |
| Day 7 to Day 14 | p = 0.25 | p = 0.42 |
| Decline | ES = 0.40 (n = 5) | ES = 0.24 (n = 5) |
| No Decline | ES = 0.08 (n = 24) | ES = 0.04 (n = 24) |
Abbreviations: CDLQI Children’s Dermatology Life Quality Index, DLQI Dermatology Life Quality Index, NRS Numeric rating scale, PGIS Patient Global Impression of Severity, POEM Patient Oriented Eczema Measure, ES Effect size
[a]The NRS scales ranged from 0 to 10
[b]Test-retest calculation assessed score changes from Day 7 and Day 14 and the Week 1 to Week 2 average in patients who showed a 0- or 1-point change on the PGIS scale
[c]Correlations performed on Day 1, 7, 14, and the Week 1 to Week 2 average except for PGIS, which was only collected at Day 7 and 14
[d]p-value from test for difference in mean score change of participants who scored above and below 4 on the PGIC between Weeks 1 and 2 and Day 7 and Day 14