TABLE 2.
Effect of loss of PmrA on colistin susceptibility and PmrB mutations in the strain panel
| Strain designation | Colistin MIC (μg/ml)a
|
PmrB mutations (amino acid substitutions) | |
|---|---|---|---|
| Wild type | ΔpmrA | ||
| ATCC 17978 | 0.25 | 0.25 | Reference |
| BV94 | 64 | 32 | Wild type |
| BV95 | 32 | 0.5 | L274W |
| BV172 | 256 | 1 | Q43L and L267F |
| BV173 | 128 | 1 | A138T and A226V |
| BV174 | 64 | 1 | Q277R |
| BV175 | 256 | 0.5 | L267W |
| BV185 | 256 | 0.25 | P233S |
| BV186 | 16 | 0.25 | Q277R |
| BV187 | 16 | 0.25 | Q277R |
| BV189 | 64 | 64 | Wild type |
| BV190 | 256 | 0.5 | A138T and A226V |
| BV191 | 256 | 0.25 | A138T and P233S |
a
Susceptibility breakpoint, ≤2 μg/ml. Susceptible, italics; resistant, bold.